Selected publications
1. Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X & Zhang ZR*. (2023) UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. Biochim Biophys Acta Gene Regul Mech. 1866: 194937
2. Hou X, Zhang X, Zou H, Guan M, Fu C, Wang W, Zhang ZR, Geng Y* & Chen Y*. (2023) Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4. Neuron. 111, 1898-1913
3. Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y & Zhang ZR*. (2022) TMUB1 is an endoplasmic reticulum-resident escortase that promotes p97-mediated extraction of membrane proteins for degradation. Mol Cell 82, 3453-3467
4. Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang ZR, Pan H, Qian L & Yuan J*. (2021) Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci U S A. 118(39): e2110476118.
5. Hu X, Wang L, Wang Y, Ji J, Li J, Wang Z, Li C, Zhang Y & Zhang ZR*. (2020) RNF126-mediated reubiquitination is required for proteasomal degradation of p97-extracted membrane proteins. Mol Cell 79, 320-331, Highlighted in a Mol Cell Preview
6. Shi J, Hu X, Guo Y, Wang L, Ji J, Li J & Zhang ZR*. (2019) A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation. J Biol Chem. 294, 20084-20096. Recommended in Faculty of 1000
7. Coelho JPL, Stahl M, Bloemeke N, Meighen-Berger K, Alvira CP, Zhang ZR, Sieber SA & Feige MJ*. (2019) A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. Nat Commun. 10, 672.
8. Plumb R#, Zhang ZR#, Appathurai S & Mariappan M. (2015) A functional link between the co-translational protein translocation pathway and the UPR. eLife 4, e07426 (#co-first author)
9. Park SY, Waheed AA, Zhang ZR, Freed EO & Bonifacino JS*. (2014) HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor. J. Biol. Chem. 289, 35102-35110
10. Zhang ZR*, Bonifacino JS & Hegde RS*. (2013) Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell 154, 609-622, Highlighted in a Cell Preview, Recommended in Faculty of 1000.
11. Moran C, Kinsella GK, Zhang ZR, Perrett S & Jones GW*. (2013) Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo. G3: Genes, Genomes, Genetics 3, 1409-1418
12. Emerman AB, Zhang ZR, Chakrabarti O & Hegde RS*. (2010). Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol. Biol. Cell 21, 4325-4337
13. Zhang C, Jackson A, Zhang ZR, Han Y, Yu S, He RQ & Perrett S*. (2010). Amyloid-Like aggregates of the yeast prion protein Ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis. PLoS One 5, e12529
14. Zhang ZR & Perrett S*. (2009). Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils. J. Biol. Chem. 284, 14058-14067
15. Wang XY, Zhang ZR & Perrett S*. (2009). Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys10 and His106. Biochem. J. 417, 55-64
16. Zhang ZR, Bai M, Wang XY, Zhou JM & Perrett S*. (2008). "Restoration" of glutathione transferase activity by single-site mutation of the yeast prion protein Ure2. J. Mol. Biol. 384, 641-651
17. Lian HY, Zhang H, Zhang ZR, Loovers HM, Jones GW, Rowling PJ, Itzhaki LS, Zhou JM & Perrett S*. (2007). Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J. Biol. Chem. 282, 11931-11940
