2015-至今：中国科学院生物与化学交叉研究中心，研究员、课题组长

Interdisciplinary Research Center on Biology and Chemistry, Chinese Academy of Sciences, Shanghai

2013-2015：耶鲁大学医学院，副研究科学家

Associate Research Scientist, Yale University School of Medicine, New Haven, Connecticut

2009-2012：美国国立卫生研究院，博士后

Postdoctoral Fellow, National Institutes of Health (NIH), Bethesda, Maryland

2004-2009：中国科学院生物物理研究所，生物化学博士

Ph.D., Institute of Biophysics, Chinese Academy of Sciences, Beijing

2000-2004: 山东大学生物科学系，理学学士

B.Sc., College of Life Sciences, Shandong University, Jinan

Representative publications (*corresponding author)

1.    Ji J, Cui MK, Zou R, Wu MZ, Ge MX, Li J, & Zhang ZR*. (2024) An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins. Mol Cell, In press

2.    Hu X, Zou R, Zhang Z, Ji J, Li J, Huo XY, Liu D, Ge MX, Cui MK, Wu MZ, Li ZP, Wang Q, Zhang X & Zhang ZR*. (2023) UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. BBA-Gene Regul Mech. 1866: 194937

3.    Wang L, Li J, Wang Q, Ge MX, Ji J, Liu D, Wang Z, Cao Y, Zhang Y & Zhang ZR*. (2022) TMUB1 is an endoplasmic reticulum-resident escortase that promotes p97-mediated extraction of membrane proteins for degradation. Mol Cell 82, 3453-3467

4.    Hu X, Wang L, Wang Y, Ji J, Li J, Wang Z, Li C, Zhang Y & Zhang ZR*. (2020) RNF126-mediated reubiquitination is required for proteasomal degradation of p97-extracted membrane proteins. Mol Cell 79, 320-331, Highlighted in a Mol Cell Preview

5.    Shi J, Hu X, Guo Y, Wang L, Ji J, Li J & Zhang ZR*. (2019) A technique for delineating the unfolding requirements for substrate entry into retrotranslocons during endoplasmic reticulum-associated degradation. J Biol Chem. 294, 20084-20096. Recommended in Faculty of 1000

6.    Zhang ZR*, Bonifacino JS & Hegde RS*. (2013) Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell 154, 609-622, Highlighted in a Cell Preview, Recommended in Faculty of 1000.

Other publications (#first author):

1.    Hou X, Zhang X, Zou H, Guan M, Fu C, Wang W, Zhang ZR, Geng Y* & Chen Y*. (2023) Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4. Neuron. 111, 1898-1913

2.    Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang ZR, Pan H, Qian L & Yuan J*. (2021) Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci U S A. 118(39): e2110476118.

3.    Coelho JPL, Stahl M, Bloemeke N, Meighen-Berger K, Alvira CP, Zhang ZR, Sieber SA & Feige MJ*. (2019) A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration. Nat Commun. 10, 672.

4.    Plumb R^#, Zhang ZR^#, Appathurai S & Mariappan M*. (2015) A functional link between the co-translational protein translocation pathway and the UPR. eLife 4, e07426 (#co-first author)

5.    Park SY, Waheed AA, Zhang ZR, Freed EO & Bonifacino JS*. (2014) HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor. J. Biol. Chem. 289, 35102-35110

6.    Moran C, Kinsella GK, Zhang ZR, Perrett S & Jones GW*. (2013) Mutational Analysis of Sse1 (Hsp110) Suggests an Integral Role for this Chaperone in Yeast Prion Propagation In Vivo. G3: Genes, Genomes, Genetics 3, 1409-1418

7.    Emerman AB, Zhang ZR, Chakrabarti O & Hegde RS*. (2010). Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol. Biol. Cell 21, 4325-4337

8.    Zhang C, Jackson A, Zhang ZR, Han Y, Yu S, He RQ & Perrett S*. (2010). Amyloid-Like aggregates of the yeast prion protein Ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis. PLoS ONE 5, e12529

9.    Zhang ZR^# & Perrett S*. (2009). Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils. J. Biol. Chem. 284, 14058-14067

10.  Wang XY, Zhang ZR & Perrett S*. (2009). Characterization of the activity and folding of the glutathione transferase from Escherichia coli and the roles of residues Cys10 and His106. Biochem. J. 417, 55-64

11.  Zhang ZR^#, Bai M, Wang XY, Zhou JM & Perrett S*. (2008). "Restoration" of glutathione transferase activity by single-site mutation of the yeast prion protein Ure2. J. Mol. Biol. 384, 641-651

12.  Lian HY, Zhang H, Zhang ZR, Loovers HM, Jones GW, Rowling PJ, Itzhaki LS, Zhou JM & Perrett S*. (2007). Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils. J. Biol. Chem. 282, 11931-11940